Infection biology

Utilizing the power of intravital imaging, we investigate the molecular details directing the complex alterations of the tissue homeostasis that occur during bacterial colonization of the kidney. Reciprocally, we are analyzing how the altered tissue microenvironment affects bacterial growth, gene expression pattern and biofilm formation in vivo during infection. Knowledge of the interplay between host factors and bacterial survival strategies will guide further research of identifying novel antimicrobial therapeutic strategies. - To allow for probing of altered tissue parameters in real-time during infection, we develop functionalized nanoparticles compatible with the intravital imaging approach. The nanoparticles will be used as fluorescence-based sensors, to monitor any changes that occur locally, at the site of infection, as bacterial multiplication promote the progression of infection.