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New Diagnostic test for the detection of infections caused by biofilms.

Bacteria such as Escherichia coli are known to hide during an infection by encasing themselves in slime. When they grow like this, clusters of bacteria are called a biofilm and they are hard to detect and hard to treat with antibiotics. We decided to tackle the problem by looking for the slime that protects the bacteria, instead of the bacteria themselves. The important part of this new sensor is that humans naturally do not produce any cellulose so if the sensor lights up there is a high probability that you have an infection. We collected urine samples from Karolinska University Hospital and began testing if the method would work in the clinic. The sensor not only alerts medical staff to the presence of bacteria, but it also gives information of how the bacteria are growing which is very important for treatment. Bacteria growing in biofilms are much more resistant to antibiotics and having this information can help determine the correct course of treatment. As the test is completely non-invasive, it is hoped that it could be used in the future to help diagnose stubborn urinary tract infections in patients. The article has been published in npj Biofilms $amp; Microbiomes (2018) 4:26


The Petri dish reinvented: Bringing bacterial mutant screens into the 21st century.

The Petri dish has been a staple in microbiology labs for more than 100 years. In an article we published in Lab on a Chip, we reinvented the Petri dish as a miniaturized device called the nanowell slide. Each of the 672 wells of this slide requires only 500 nanoliters of sample, significantly minimizing the amount of reagents used. Single bacterial mutants are placed in each well and monitored through the glass bottom of the slide, with the help of algorithm-assisted analysis. This enabled us to identify genes that influence bacterial growth, metabolism and morphology. By replacing the Petri dish with the nanowell slide, we hope to speed up the process of understanding gene function in bacteria.


The complicated thing about plants and biofuels.

A new publication from The Swedish Medical Nanoscience Center at Karolinska Institutet with co-authors from Linköpings universitet (Choong et al. Scientific Reports 8, Article number: 3108 (2018)) explains how plants can be used to make better biofuels using a new technique developed at The Swedish Medical Nanoscience Center. The findings are summarized in the video below.

The complicated thing about plants and biofuels. from Ben on Vimeo.


TV4 interview

Professor Agneta Richter-Dahlfors speaks about Nanomedicine in national science program on TV4. She covers nanoparticles as means of delivering pharmaceuticals, organic bioelectronics as means of controlling cellular signalling and novel imaging approaches for tissue microbiology.

Nanomedicine lecture

Professor Agneta Richter-Dahlfors speaks about Nanomedicine for students at the Nobel Museeum. Part 1.

Professor Agneta Richter-Dahlfors speaks about Nanomedicine for students at the Nobel Museeum. Part 2.

Sweden-Japan Workshop Bionano

The regular meetings between Swedish and Japanese researchers in Sweden-Japan Workshop BioNano create partnerships both across countries and across the research areas of nanotechnology and life sciences. Center director Agneta Richter-Dahlfors, says that cooperation will lead to a new generation of scientists who are able to communicate with both students and medical students, and that it will bring great benefit in the future.

DNA Origami Slotted Cross

span> Animation showing the internal structure of the DNA origami slotted cross design. This design has been rendered in DNA giving crosses that have a dimension of about 40 nm across, see our publication Douglas, Dietz, Liedl, Hogberg, Graf, Shih in Nature from May 21 2009. Shown is the DNA scaffold strand and how it is routed around in the final design. Björn Högberg lab.

DNA Visualisation of DNA origami folding

The animation shows how a DNA scaffold strand (blue) assumes the final shape of a DNA origami six-helix bundle. The short DNA strands that enter the scene at a later stage are the so called staples. The staples force the DNA scaffold to fold by hybridizing to different parts of the scaffold, stapling it toghether. This is certainly not what the actual folding looks like, but is intended to show how our DNA origami structures are connected together. Björn Högberg lab.

Scientific Visualization and Presentation in 3D

span>Modelling in Maya. For the Karolinska Institutet PhD course in Scientific Visualization and presentation in 3D (2630). Björn Högberg lab.

Olof Einarsson

A project of future bio-design in collaboration with Swedish Medical Nanoscience Center and University College of Arts, Crafts and Design. Biomass and biofilm produced by bacteria can be the future building material in an ecology driven society.

Uropathogenic E.coli; Infection model and virulence factors

To view an animated summary of our results so far, click on the black box below.

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