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May
24

New Publication in Lab on a Chip

Publication in Lab on a Chip:

"A universal platform for selection and high-resolution phenotypic screening of bacterial mutants using the nanowell slide."

The Petri dish has been a staple in microbiology labs for more than 100 years. In an article we published in Lab on a Chip, we reinvented the Petri dish as a miniaturized device called the nanowell slide. Each of the 672 wells of this slide requires only 500 nanoliters of sample, significantly minimizing the amount of reagents used. Single bacterial mutants are placed in each well and monitored through the glass bottom of the slide, with the help of algorithm-assisted analysis. This enabled us to identify genes that influence bacterial growth, metabolism and morphology. By replacing the Petri dish with the nanowell slide, we hope to speed up the process of understanding gene function in bacteria.

link to the article

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Feb
15

New Publication in Scientific Reports

Publication in Scientific Reports:

"Stereochemical identification of glucans by oligothiophenes enables cellulose anatomical mapping in plant tissues"

The publication from The Swedish Medical Nanoscience Center at Karolinska Institutet with co-authors from Linköpings universitet explains how plants can be used to make better biofuels using a new technique developed at The Swedish Medical Nanoscience Center. The findings are summarized in the video below.

link to the article

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Dec
08

PhD thesis defense Salvador Gomez-Carretero

PhD thesis defense Salvador Gomez-Carretero

"Prevention of bacterial colonization in hospital-acquired infections using electrically conducting polymers"

Electrically conducting polymers have recently emerged as an interesting group of materials with properties from organic polymer, metals and semiconductors. With their dual organic-conductive nature, these materials can be used to synthetize versatile electrochemical systems with which monitor and influence biological systems. In this thesis, the use of electrically conducting polymers is explored with the aim of modulating biofilm formation. [Excert from the thesis abstract]

link to the thesis

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Oct
10

Agneta Richter-Dahlfors receives SSFs price for Innovation

Agneta Richter-Dahlfors receives SSFs price for Innovation

In the price announcement from the Swedish Foundation for Strategic Research (SSF) is says: "The winner of the prize, Agneta Richter-Dahlfors, is Professor of Cellular Microbiology at Karolinska Institutet and director of the multidisciplinary research environment Swedish Medical Nanoscience Center. In its SSF-supported project, Richter-Dahlfors has further developed research results for innovations and used the resources for patenting, products and companies - according to SSF's goals and guidelines."

science

link to SSFs homepage

The price announcement was also featured by the following Media outlets:

  • Karolinska Institutet -- News
  • Kemivärlden Biotech
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Sep
05

New Publication in npj Biofilms & Microbiomes

Publication in npj Biofilms & Microbiomes:

"Redox-active conducting polymers modulate Salmonella biofilm formation by controlling availability of electron acceptors"

In this publication, we describe how redox active surfaces based on the conducting ploymer PEDOT can be used to modulate bacterial metabolism in order to enhance or prevent biofilm formation on surfaces.

link to the article

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Aug
15

Publication in Advanced Healthcare Materials

Publication in Advanced Healthcare Materials

"Electroenhanced Antimicrobial Coating Based on Conjugated Polymers with Covalently Coupled Silver Nanoparticles Prevents Staphylococcus aureus Biofilm Formation"

As the antimicrobial effect of silver nanoparticles (AgNP) has been well described, we aimed to functionalize surfaces based on the conducting polymer PEDOT by covalent coupling of AgNPs. Using the functionalized PEDOT-AgNP surfaces we investigate biofilm formation of Staphylococcus aureus on these surfaces. We show that the coupling of AgNPs to the organic bioelectronic surfaces minimized biofilm formation of Staphylococcus aureus. Interestingly, application of a 5 Hz square wave potential to the PEDOT-AgNP functionalized surfaces leads to complete abolishment of biofilm formation.

link to the article

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Jun
30

News: Interdisciplinary Synergy

An article about Synergy at The Swedish Medical Nanoscience Center

"Tvärvetenskaplig Synergi" published in Framtidens Forskning June 30 2017

link to the article

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May
30

PhD thesis defense Ferdinand Xiankeng

PhD thesis defense Ferdinand Xiankeng

"Tissue microbiology : an integrated approach for intravital studies of host-pathogen interactions"

Bacteria colonizing the host microenvironment adopt a multicellular lifestyle to resist efforts of innate immunity and early-induced innate responses. While showing all indications of being a biofilm, no method exists to verify or study this in vivo. To overcome this we developed an optical method for continuous in situ analysis of biofilms. This was based on luminescent conjugated oligothiophenes (LCOs), a non-toxic small molecular fluorophore. This chameleon like oligomers allowed specific detection of Salmonella extracellular matrix (ECM) curli fibers and cellulose via a target specific optical signature, and enabled dynamic tracking of their formation in a variety of growth models. Named Optotracing, this technology uncovered a rare glimpse of cellulose in intracellular bacteria, in eukaryotic cells and infected tissues. [Excert from the thesis abstract]

link to the thesis

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Jan
25

News: Molecular chameleons detect bateria

Interview with Agneta Richter Dahlfors about the new Optotracing technology:

"Molekylära kameleonter hittar bakteriarna" published in Naturvetare Nr. 1 2017

link to the article

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Jan
16

Publication in Journal of Controlled Release

Publication in Journal of Controlled Release:

"Electrochemically triggered release of acetylcholine from scCO2 impregnated conductive polymer films evokes intracellular Ca2+ signaling in neurotypic SH-SY5Y cells"

In this publication, we present a method for electronically triggered release of the quaternary ammoniumcation acetylcholine (ACh) from an impregnated conductive polymer film. Using supercritical carbon dioxide (scCO2), a dry film of PEDOT/PSS is impregnated with the cationic drug.

link to the article

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