The Swedish Medical Nanoscience Center at Karolinska Institutet is a novel initiative aimed to promote efficient integration of cutting edge technologies and medical research.
The Swedish Medical Nanoscience Center at Karolinska Institutet is uniquely positioned within the medical faculty where medical problems guide the nanoscience development within a setting that offers a blend of technological, pre-clinical and clinical expertise.The Swedish Medical Nanoscience Center will act as a knowledge hub on the national and international arena, forming a physical platform where scientists from the fields of medicine and engineering intimately collaborate in real life. This will foster a new breed of scientists with true interdisciplinary knowledge.
Agneta Richter-Dahlfors
Cancer
Generic nanoparticle systems are developed as delivery vehicles of chemotherapeutics in breast and prostate cancers. Their modular construction allows for specific tailoring of pharmacokinetic profiles and biodistribution to match a specific application or disease. Read more >>
Infection biology
Real-time analysis of progr-ession of bacterial infections in organs of live animals: Utilizing the power of intravital imaging, we investigate the molecular details directing the complex alterations of the tissue homeostasis that occur during bacterial colonization of the kidney. Reciprocally, we are analyzing how the altered tissue microenvironment affects bacterial growth, gene expression pattern and biofilm formation in vivo during infection. Read more >>
Neuroscience
Circadian rhythm distu-rbances in psychiatric disorders are studied using skin cells from bipolar and schizophrenic patients. Using molecular imaging in transgenic mice, we investigate i) effect of psychopharmacological drugs on clock gene expression, ii) psychosocial stress and molecular rhythms, iii) stress-tolerance at certain times of the day.
The “artificial nerve cell”: We recently developed an “organic electronic ion pump” to precisely deliver neuro-stimulatory substances. Read more >>
Novel tools
Nanoparticles for targeted multimodal diagnostic imaging are designed for SPECT and 19F-MRI utilizing non-ra-dioactive 19F for detection.
DNA nanotechnology: Designed DNA devices to study molecular interactions with cell membrane functions including endocytosis, exocytosis and lysis.
Organic bioelectronics: We develop an array of organic electronic devices, translating electronic input signals to delivery of chemical subst-ances. Read more >>